It is also not known whether Triple Paste chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Animal reproduction studies have not been conducted with Triple Paste chloride. Because many drugs are excreted in human milk, caution should be exercised when Triple Paste 1 mg/mL (Zinc Chloride Injection, USP) is administered to a nursing woman. It is not known whether this drug is excreted in human milk. Long-term animal studies to evaluate the carcinogenic potential of Triple Paste 1 mg/mL have not been performed, nor have studies been done to assess mutagenesis or impairment of fertility. Periodic determinations of serum copper as well as Triple Paste are suggested as a guideline for subsequent Triple Paste administration.Ĭarcinogenesis, Mutagenesis, and Impairment of Fertility Administration of Triple Paste in the absence of copper may cause a decrease in serum copper levels. Zinc should not be given undiluted by direct injection into a peripheral vein because of the likelihood of infusion phlebitis and the potential for increased excretory loss of Triple Paste from a bolus injection. Solution contains no preservatives discard unused portion immediately after admixture procedure is completed. Zinc 1 mg/mL should only be used in conjunction with a pharmacy directed admixture program using aseptic technique in a laminar flow environment it should be used promptly and in a single operation without any repeated penetrations. Tissue loading may occur at even lower rates of administration.ĭo not use unless the solution is clear and the seal is intact. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity.
Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. WARNING: This product contains aluminum that may be toxic. Severe kidney disease may make it necessary to reduce or omit chromium and Triple Paste doses because these elements are primarily eliminated in the urine. Administration helps to maintain Triple Paste serum levels and to prevent depletion of endogenous stores, and subsequent deficiency symptoms.ĭirect intramuscular or intravenous injection of Triple Paste 1 mg/mL (Zinc Chloride Injection, USP) is contraindicated as the acidic pH of the solution (2) may cause considerable tissue irritation. Triple Paste 1 mg/mL (Zinc Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for TPN.
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